A Pilot Case Study on Innovative Behaviour: Lessons Learned and Directions for Future Work

Context: A case study is a powerful research strategy for investigating complex social-technical and managerial phenomena in real life settings. However, when the phenomenon has not been fully discovered or understood, pilot case studies are important to refine the research problem, the research variables, and the case study design before launching a full-scale investigation. The role of pilot case studies has not been fully addressed in empirical software engineering research literature. Objective: To explore the use of pilot case studies in the design of full-scale case studies, and to report the main lessons learned from an industrial pilot study. Method: We designed and conducted an exploratory case study to identify new relevant research variables that influence the innovative behaviour of software engineers in the industrial setting and to refine the full-scale case study design for the next phase of our research. Results: The use of a pilot case study identified several important research variables that were missing in the initial framework. The pilot study also supported a more sophisticated case study design, which was used to guide a full-scale study. Conclusions: When a research topic is has not been fully discovered or understood, it is difficult to create a case study design that covers the relevant research variables and their potential relationships. Conducting a full-scale case study using an untested case design can lead to waste of resources and time if the design has to be reworked during the study. In these situations, the use of pilot case studies can significantly improve the case study design

Using Meta-Ethnography to Synthesize Research: A Worked Example of the Relations between Personality on Software Team Processes

Context: The increase in the number of qualitative and mixed-methods research published in software engineering has created an opportunity for further knowledge generation through the synthesis of studies with similar aims. This is particularly true in the research on human aspects because the phenomena of interest are often better understood using qualitative research. However, the use of qualitative synthesis methods is not widespread and worked examples of their consistent application in software engineering are needed. Objective: To explore the use of meta-ethnography in the synthesis of empirical studies in software engineering through an example using studies about the relations between personality and software team processes. Methods: We applied the seven phases of meta-ethnography on a set of articles selected from a previously developed systematic review, to assess the appropriateness of meta-ethnography in this domain with respect to ease of use, and usefulness and reliability of results. Results: Common concepts were identified through reading and interpreting the studies. Then, second order translations were built and used to synthesize a model of the relationships between personality and software team processes. Conclusions: Meta-ethnography is adequate in the synthesis of empirical studies even in the context of mixed-methods studies. However, we believe that the method should not be used to synthesize studies that are too disparate to avoid the development of gross generalizations, which tend to be fruitless and are contrary to the central tenets of interpretive research

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular platform that promotes inflammation via cleavage and activation of key inflammatory molecules including active caspase-1 (Casp1p20), IL-1β, and IL-18. Although participation of the inflammasome in COVID-19 has been highly speculated, the inflammasome activation and participation in the outcome of the disease are unknown. Here we demonstrate that the NLRP3 inflammasome is activated in response to SARS-CoV-2 infection and is active in COVID-19 patients. Studying moderate and severe COVID-19 patients, we found active NLRP3 inflammasome in PBMCs and tissues of postmortem patients upon autopsy. Inflammasome-derived products such as Casp1p20 and IL-18 in the sera correlated with the markers of COVID-19 severity, including IL-6 and LDH. Moreover, higher levels of IL-18 and Casp1p20 are associated with disease severity and poor clinical outcome. Our results suggest that inflammasomes participate in the pathophysiology of the disease, indicating that these platforms might be a marker of disease severity and a potential therapeutic target for COVID-19

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P ConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease